Profiling the sixth base

Sequencing the sixth base (5-hydroxymethylcytosine): selective DNA oxidation enables base-pair resolution.

the family of ten-eleven-translocation (TET) oxygenases converts 5mC to 5hmC. Last year, the two more highly oxidized congeners of 5hmC, 5-formylcytosine and 5-carboxycytosine (5fC and 5caC respectively), were also discovered as 5mC TET oxidation products. The race to disentangle the roles that these “new” DNA bases play, both as epigenetic markers and as intermediates in demethylation pathways...

Complexity Profiling for Informed Case-Base Editing

The contents of the case knowledge container is critical to the performance of case-based classification systems. However the knowledge engineer is given little support in the selection of suitable techniques to maintain and monitor the case-base. In this paper we present a novel technique that provides an insight into the structure of a case-base by means of a complexity profile that can assis...

The Sixth Framework Programme

1. Project summary In this project we aim to invent and develop new techniques for the retrieval of figurative images (such as clip art, logos, signs) from large databases. Our techniques will be based on the extraction and matching of perceptually relevant shape features, thereby overcoming many of the limitations of existing methods. This project will develop and evaluate new algorithms for: ...

The Sixth Annual

The Sixth Annual Mlsp

For the Sixth Annual Machine Learning for Signal Processing competition, which is sponsored by Nokia and PASCAL2, entrants were asked to develop a classifier, with optional feature extraction, that uses only electroencephalography (EEG) data collected during an image presentation (visual oddball) task and optimally determines whether each image presented to a user contains or does not contain a...